Myeloid -derived suppressor cells and Multiple myeloma Ryleigh Mo - Grade 11 University of Toronto schools, Toronto, Ontario, Canada.

Myeloid -derived suppressor cells and Multiple myeloma Ryleigh Mo - grade 11 University of Toronto schools, Toronto, Ontario, Canada The myeloma microenvironment refers to the specialized environment surrounding multiple myeloma cells within the bone marrow. Multiple myeloma is a cancer of the plasma cells, a type of white blood cell that produces antibodies. The tumor cells in multiple myeloma can disrupt the normal functioning of the bone marrow and interact with various components of the surrounding microenvironment. The myeloma microenvironment is complex and consists of various cell types, including immune cells, stromal cells, and endothelial cells, as well as extracellular matrix components and soluble factors such as cytokines and growth factors. These components interact with the myeloma cells in a dynamic manner, influencing their growth, survival, and response to therapy. Understanding the myeloma microenvironment is critical for developing effective therapies for multiple myeloma, as targeting interactions between myeloma cells and their microenvironment has emerged as a promising approach for treatment. Additionally, the microenvironment plays a role in disease progression and the development of drug resistance in multiple myeloma. Text