Targeting Tumour-Associated Macrophages for Multiple Myeloma Therapy Alexander Wong University of Toronto Schools Sun Life Gene Medical Science Institute Cancer Research Program Student, Toronto, Ontario, Canada

09082024 Alexander Wong-Targeting Tumour-Associated Macrophages for Multiple Myeloma Therapy Research Paper (1).pdfTargeting Tumour-Associated Macrophages for Multiple Myeloma Therapy

Alexander Wong   University of Toronto Schools Sun Life Gene Medical Science Institute Cancer Research Program Student, Toronto, Ontario, Canada

Abstract: Multiple myeloma (MM) is a hematologic malignancy characterized by the accumulation of malignant plasma cells in the bone marrow. Tumour-associated macrophages (TAMs) play a crucial role in the tumour microenvironment of MM, contributing to tumour progression, immune evasion, and drug resistance. Recent studies have highlighted the potential of targeting TAMs as a therapeutic strategy for MM, with various therapies being developed. This paper aims to explore the therapeutic potential of various TAMs in relation to MM as a method for treatment. To do so, various scientific studies have been analyzed, utilizing the data for various antibody therapies and their results to explore their potential as viable treatments. Ultimately, recent developments have shown that these therapies are indeed effective and can inhibit the progression of MM, paving the way for combating the proliferation of MM cells.

 Keywords: tumour-associated macrophage; therapies; multiple myeloma; microenvironment; angiogenesis.